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Thursday, July 30, 2020 | History

1 edition of Protein traffic in parasites and mammalian cells found in the catalog.

Protein traffic in parasites and mammalian cells

Protein traffic in parasites and mammalian cells

proceedings of a workshop held at the International Laboratory for Research on Animal Diseases, Nairobi, Kenya, 29 August to 1 September 1988

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  • 35 Currently reading

Published by International Laboratory for Research on Animal Diseases in Nairobi, Kenya .
Written in English

    Subjects:
  • Proteins -- Metabolism -- Disorders -- Congresses.,
  • Trypanosomiasis -- Congresses.,
  • Theileriosis -- Congresses.

  • Edition Notes

    Includes bibliographical references.

    Statementorganized by the International Laboratory for Research on Animal Diseases ; with support from the United Nations Development Programme ; scientific editor, J.D. Lonsdale-Eccles ; production editor, J.K. Lenahan.
    ContributionsLonsdale-Eccles, J. D., International Laboratory for Research on Animal Diseases.
    Classifications
    LC ClassificationsQP552.C34 P76 1989
    The Physical Object
    Paginationx, 160 p. :
    Number of Pages160
    ID Numbers
    Open LibraryOL2024908M
    ISBN 109290552905
    LC Control Number90981564

      Protein Prenyltransferases: Anchor Size, Pseudogenes and Parasites Protein Prenyltransferases: Anchor Size, Pseudogenes and Parasites Maurer-Stroh, S.; Washietl, S.; Eisenhaber, F. Introduction As the sequences of complete genomes have become available, the next logical step is to move on to the encoded proteome and elucidate its temporal, . Chlamydiae are extremely successful pathogens of humans and animals. The chlamydial developmental cycle may be considered superficially analogous to bacterial sporulation in that it consists of an environmentally stable cell type, called the elementary body (EB), and a functionally and morphologically distinct vegetative cell type, termed the reticulate body (RB).

    cells protein cancer apoptosis activation tumor autophagic induced proteins pathway ros Whether you've loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them., . Protein kinase C (PKC)-related cDNA clones encode an 84 kd protein, nPKC. nPKC contains a cysteine-rich repeat sequence homologous to that seen in conventional PKCs (α, βI, βII, and γ), which make up a family of 77–78 kd proteins with closely related sequences. nPKC, when expressed in COS cells, confers increased high-affinity phorbol ester receptor activity to intact cells.

    Metabolic adaptation reactions are common when prokaryotes interact with eukaryotic cells, especially when the bacteria are internalized by these host cells. Such adaptations lead to significant changes in the metabolism of both partners. While the final outcome may be sometimes beneficial (e.g., in case of insect endosymbiosis) or (mainly) neutral for the interacting partners (e.g.   Trypanosoma cruzi (T. cruzi) is a protozoan parasite that causes Chagas disease, a zoonotic disease that can be transmitted to humans by blood-sucking triatomine bugs. T. cruzi is a single-celled eukaryote with a complex life cycle alternating between reduviid bug invertebrate vectors and vertebrate hosts. This article will look at the developmental stages of T. cruzi in the invertebrate.


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Protein traffic in parasites and mammalian cells Download PDF EPUB FB2

The correct citation for this book is: International Laboratory for Research on Animal Diseases. Protein Traffic in Parasites and Mammalian Cells: Proceedings of a Workshop Held at the International Laboratory for Research on Animal Diseases.

Get this from a library. Protein traffic in parasites and mammalian cells: proceedings of a workshop held at the International Laboratory for Research on Animal Diseases, Nairobi, Kenya, 29 August to 1 September [J D Lonsdale-Eccles; International Laboratory for Research on.

Eosinophil cationic protein (ECP) also known as ribonuclease 3 is a basic protein located in the eosinophil primary matrix. In humans, the eosinophil cationic protein is encoded by the RNASE3 gene.

ECP is released during degranulation of protein is related to inflammation and asthma because in these cases, there are increased levels of ECP in the s: RNASE3, ECP, RNS3, RAF1, ribonuclease A.

In book: Encyclopedia of Industrial Biotechnology. or insect cells, protein expression in mammalian cells is often obligatory to produce proteins in an enzymatic or biologically active form. Intracellular Parasites Actively Invade Host Cells The uptake of viruses by receptor-mediated endocytosis and bacteria by phagocytosis requires energy provided by the host cell.

The pathogen is a relatively passive participant, usually providing a trigger to initiate the invasion process, but not contributing any metabolic by: In mammalian cells, protein targets of BFA, all associated with Golgi membranes, include a mono-ADP-ribosyltransferase that is activated by BFA 3 and two BFA-inhibited guanine nucleotide-exchange proteins, BIG1 and BIG2.

4–7 These proteins accelerate GTP binding by, and thus activation of, ADP-ribosylation factors or ARFs. Live cells (♦), dead cells (), and unlabeled cells (). Immunofluorescence showed that p67 was dispersed in parasites expressing the Q71L mutant (Supplemental Figure 4 B), confirming that the post-Golgi trafficking defect described above is due to an excess in functionally active Arf1.

Interestingly, however, we found that the p90ATF6 level decreased, and instead a new band of 50 kDa (p50ATF6) appeared in ER-stressed cells before the induction of GRP78, a major target protein of the mammalian UPR (Yoshida et al., ).

As the anti-B03N antiserum used in the previous study reacted with multiple proteins present in HeLa cell. from book Membrane trafficking: Second set of ESCRT machinery components for phagophore closure in mammalian cells.

View. parasites recruited LC3 protein and. Recent studies suggest that protein fatty-acylation is essential to survival and pathogenesis of eukaryotic pathogens such as parasites and fungi. Moreover, fatty-acylation in host cells can be exploited or manipulated by pathogenic bacteria. First, Stx5 is regulated by other SNAREs, because in mammalian cells, overexpression of mutant forms of Bet1L, the v-SNARE of retrograde trafficking, results in altered distribution of Stx5, its SNARE partner GosR1, and the medial-Golgi protein Golgi mannosidase II to cis-Golgi and ER, possibly because of increased retrograde transport of Stx5.

With its acclaimed author team, cutting-edge content, emphasis on medical relevance, and coverage based on landmark experiments, Molecular Cell Biology has justly earned an impeccable reputation as an authoritative and exciting text.

The new Sixth Edition features two new coauthors, expanded coverage of immunology and development, and new media tools for students and instructors.3/5(7). Importantly, depletion of the protein significantly reduced parasites survival in macrophages and markedly attenuated their virulence in mice.

Altogether, this shows TgATG9 is important for the fate of Toxoplasma in immune cells and contributes to the overall virulence of the parasite, possibly through an involvement in a canonical autophagy.

John David Lonsdale-Eccles, English biochemist, educator, researcher. He was hon. representative of the consular department British High Commission, Nairobi, Kenya, Fellow Royal Society Chemistry; member New York Academy Sci., American Society Cell. In mammalian cells, ER membrane-resident complexes containing E3 ligases such as HRD1 and GP78, and other regulatory components such as EDEM1, SEL1L, ERManI, and HERP control the ERAD pathway.

P97/VCP protein and its co-factors also play a role in the pathway (DeLaBarre et al., ; Nowis et al., ). Unfolded/misfolded proteins are. Viruses are intracellular parasites that commandeer cellular processes, such as RNA processing or protein synthesis, to perform virus-specific functions.

For this purpose, many viral proteins shuttle between the nuclear and cytoplasmic compartments, even when the. Dobrowolski JM, Sibley LD () Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite. Cell – View Article Google Scholar 8. Morisaki JH, Heuser JE, Sibley LD () Invasion of Toxoplasma gondii occurs by active penetration of the host cell.

Protein trafficking in disease The highly co-ordinated movement of the thousands of distinct membrane proteins between the cell surface and intracellular compartments is a critical factor in health and disease. This movement controls the organisation of cells in tissues and communication between cells.

The endomembrane system separates the cell into different compartments, or organelles, such as the nucleus, the endoplasmic reticulum (ER), the Golgi apparatus, and lysosomes (see Table ).The endomembrane system is derived from the ER and flows to the Golgi apparatus, from which lysosomes bud. The ER is a continuous system of flattened membrane sacks and tubules that is specialized for.

Eukaryotic cells consist of numerous membrane-bound organelles, which compartmentalize cellular materials to fulfil a variety of vital functions. In the post-genomic era, it is widely recognized that identification of the subcellular organelle localization and transport mechanisms of the encoded proteins are necessary for a fundamental understanding of their biological functions and the.

The organelles of endosymbiotic origin, plastids, and mitochondria, evolved through the serial acquisition of endosymbionts by a host cell.

These events were accompanied by gene transfer from the symbionts to the host, resulting in most of the organellar proteins being encoded in the cell nuclear genome and trafficked into the organelle via a series of translocation complexes.Toxoplasma gondii and malaria parasites contain a unique and essential relict plastid called the apicoplast.

Most apicoplast proteins are encoded in the nucleus and are transported to the organelle via the endoplasmic reticulum (ER). Three trafficking routes have been proposed for apicoplast membrane proteins: (i) vesicular trafficking from the ER to the Golgi and then to the apicoplast, (ii.

Lactoferrin is an iron-binding glycoprotein of the innate immune system, which is present in some mammalian fluids and secreted into the mucosae; it is also produced by the secondary granules of the polymorphonuclear neutrophils and secreted at infection sites.

Lactoferricins (Lfcins) are peptides derived from the N-terminus of Lf. Lf avoids the iron availability to parasites in the body.